PickCrafter

The description for this achievement is misleading (or outdated). It's not enough to unlock all the PPS items, you also need all 3 Lucky Event pickaxes as well.
Clover Pickaxe
Celtic Staff
Clover Wand

In the ascension tree, you'll need to unlock Lair of the Fates which is the upgraded Chronos' Lair Biome. This will then unlock a new mob with multiple arms and knives that spawns periodically. However, it'll take roughly 1500 drops from those mobs and while craftable, has a long line of crafting. Defeating the mob will also only net you a small amount of drops even with increased drop rate.

However, in the ascension tree, you can unlock auto-activate skills:
More Picks → Ascendant Explorer → Ascendant Idler → Ascendent Worker → Ability Cap Increase → Extra Ability → Ability Auto Clicker

With this ability auto clicker, equip the Snowball Ability and set it to automatically activate and then AFK on the Lairs of the Fate biome overnight. You can combine this with reload to lower the cooldown overall to get more activations. Any mob that is destroyed using hte snowball also drops significantly more item drops as well.

Just ascend 12 time's, more pain i guess

The achievmenet pops when you press the button to start the wheel.

I would recommend using 10 runic for a re-roll, but anything more is just a waste imho. Save it for the fire pickaxe

You'll want to get 75% crit rate.

You can combine the Glowstone Pickaxe (Nether biome) with the Potion of Critical Strike while leveling up your Frequent Criticals skill in the Player Tree.

Signalite is a super rare material in the Blighted Planet.

You'll want to be in a relatively new ascension so you have low prestige. You'll need 10 prestige to get to the Blighted Planet, then for signalite you can either craft them with the furnaces or you can defeat bosses and combine that with the Rare Block Seeker to increase rare block chances into the chests. Repeat until you upgrade the Signalite Crossbow based on the number of prestiges you have.

I've got this unlocked after reaching the Void biome and buying one of the armor pieces there. Not sure if that the intended way to unlock it, but that how it works in the 6.0.10 version of the game (which is the current build as of March 2024).

Defeat the Business Bunny boss 10 times during the Egg Hunt event.
It appears as every other boss during the event and the cooldown can be skipped using Picks/Runic/Event items (carrots).